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Cost comparison only — not medical advice
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Drug Prices

Linzess Price by Country: $282 in the US, about $54 in the UK

Europe sells linaclotide as Constella. Here is what 30 days of the 290 mcg capsule cost in seven places — and how the US list price halved in 2026.

November 2026 · Updated November 6, 2026 · By Wellness Vision 5 min read 15 sources

Researched with AI assistance; every figure is checked against the primary source cited on this page before publishing. How we work →

Key Takeaways

  • The US list price halved in 2026. AbbVie lists Linzess at $282.48 a month as of January 2026; CMS’s 2024 list price was $539. US pharmacies’ cost for a 290 mcg capsule fell from $18.15 to $9.03 on January 1, 2026 (CMS NADAC).
  • $136 for Medicare from 2027. Medicare’s negotiated price for a 30-day supply takes effect on January 1, 2027 — 75% below the 2024 list price, according to CMS.
  • Europe: about $54 to $96 for 30 days. Official prices for Constella 290 mcg, scaled from packs of 28 to 30 capsules and converted at ECB rates: UK $54, the Netherlands $62, Austria $85, Switzerland $96 (our calculation).
  • Not every country lists it. France’s public medicines database has no linaclotide product, and Germany has no statutory price ceiling (Festbetrag) for it; we found no official German price.

Linzess / Constella Price by Country (November 2026)

Linzess 290 mcg (sold in Europe as Constella 290 mcg), one capsule a day for irritable bowel syndrome with constipation — so 30 days = 30 capsules. In the US the 72 and 145 mcg capsules cost practically the same. European packs hold 28 capsules; we scale to 30 (our calculation: pack price ÷ 28 × 30). US dollars at European Central Bank reference rates of November 5, 2026. The price types differ — list price, negotiated price, pharmacy acquisition cost, retail price — and are labelled.

30 days = 30 capsules of 290 mcg. US: AbbVie list price (January 2026), CMS negotiated price for 2027 (fact sheet, November 2025), CMS NADAC (as of November 4, 2026). UK: NHS dm+d. Switzerland: BAG public price. Austria: Erstattungskodex, November 2026 (excl. VAT). Netherlands: Zorginstituut average price (to November 1, 2026). Packs of 28 scaled to 30 capsules and converted at ECB rates of November 5, 2026 (our calculation).
CountryOfficial price30 days in US dollarsWhat a patient typically pays
🇺🇸 United States (list)$282.48 a month (AbbVie, as of Jan 2026)$282About 92% of commercial prescriptions cost $0–$50 a month with the maker’s savings card (maker’s figure)
🇺🇸 United States (pharmacy cost)$9.01398 per 290 mcg capsule (CMS NADAC, Nov 4, 2026)$270—
🇺🇸 United States (Medicare, 2027)$136 negotiated price per 30-day supply, from Jan 1, 2027 (CMS)$136About 93% of Part D prescriptions cost $0–$50 a month, depending on coverage phase (maker’s figure)
🇬🇧 United KingdomConstella £37.56 for 28 capsules (NHS price, since Feb 14, 2013)$54£9.90 per item in England; free in Scotland, Wales and Northern Ireland
🇨🇭 SwitzerlandConstella CHF 73.25 for 28 capsules (public price)$9610% share after the annual deductible
🇦🇹 AustriaConstella €71.00 for 28 capsules (social-insurance price excl. VAT; effective price may be lower under a price model)$85€7.55 prescription fee per pack; insurer approval needed first
🇳🇱 NetherlandsConstella €51.88 for 28 capsules (average pharmacy price)$62Fully reimbursed; counts toward the annual deductible
🇫🇷 FranceNo linaclotide product in the public medicines database——
🇩🇪 GermanyNo statutory price ceiling (Festbetrag) for linaclotide; no official price found——

We compare prices; we do not recommend where to buy medicine. Whether to take or switch a medicine for constipation is a decision for your doctor.

What the Numbers Mean

Why the US list price fell by half

AbbVie’s list price of $282.48 a month (January 2026) is about 52% of the $539 that CMS recorded for 2024 (our calculation: $282.48 ÷ $539). The drop shows in pharmacy costs too: NADAC for a 290 mcg capsule was $18.14687 from December 17, 2025 and $9.02534 from January 1, 2026 — about $544 and $271 for 30 capsules (our calculation). AbbVie does not give a reason on its price page.

Medicare’s price takes effect in 2027

The $136 is the price Medicare negotiated under the Inflation Reduction Act for a 30-day supply, effective January 1, 2027. Pharmacies that dispense to Medicare patients are refunded the difference by the drug maker afterwards (CMS). In 2024 about 632,000 people with Medicare Part D used Linzess, and Part D spent $2.0 billion on it before rebates (CMS).

Europe: official prices well below the US

The UK, the Netherlands, Austria and Switzerland publish an official price for Constella 290 mcg — about $54 to $96 for 30 capsules at ECB rates, or 19% to 34% of the US list price (our calculation: $54 ÷ $282 and $96 ÷ $282). Even Medicare’s 2027 price is above all four. France does not list linaclotide, and Germany has neither a price ceiling nor a freely published official price for it.

Frequently Asked Questions

How much does Linzess cost in the US compared with other countries?

AbbVie lists Linzess at $282.48 a month (as of January 2026), and US pharmacies paid about $270 for 30 capsules of 290 mcg in November 2026 (CMS NADAC). Medicare’s negotiated price from January 1, 2027 is $136 for a 30-day supply (CMS). In Europe, linaclotide is sold as Constella: £37.56 for 28 capsules in the UK, €51.88 in the Netherlands, €71.00 in Austria (excl. VAT) and CHF 73.25 in Switzerland — about $54 to $96 for 30 days at ECB rates.

Is Constella the same as Linzess?

Both contain linaclotide. In Europe, Constella is authorised as a 290 mcg capsule for irritable bowel syndrome with constipation (EMA); in the US, Linzess also comes as 72 and 145 mcg capsules, which cost practically the same per capsule (NADAC).

Why did Linzess get cheaper in the US in 2026?

AbbVie’s list price is $282.48 a month as of January 2026, about half of the 2024 list price of $539 (CMS). The national pharmacy acquisition cost per 290 mcg capsule fell from $18.15 to $9.03 on January 1, 2026 (NADAC). AbbVie’s price page does not give a reason.

What do patients pay?

AbbVie says about 92% of commercially insured prescriptions cost $0–$50 a month with its savings card, and about 93% of Medicare Part D prescriptions $0–$50 depending on coverage phase. In England each prescription item costs £9.90; in Switzerland insured patients pay a 10% share after the deductible; in Austria a €7.55 prescription fee after the insurer approves it; in the Netherlands it is fully reimbursed but counts toward the annual deductible.

Is there a generic Linzess?

Not that we found: the US national pharmacy price survey (NADAC, November 4, 2026) lists only Linzess, and the UK’s dm+d lists only Constella.

Sources

  1. AbbVie — Linzess financial support: "The list price, also known as the Wholesale Acquisition Cost (WAC), for LINZESS is $282.48 a month (as of January 2026)"; out-of-pocket shares for commercial and Medicare Part D prescriptions
  2. CMS — Negotiated prices for initial price applicability year 2027 (fact sheet, November 2025): Linzess $136 negotiated price for a 30-day supply, $539 list price (2024), 75% lower; 632,000 Part D enrollees, $1,982,587,000 gross Part D costs in 2024
  3. CMS — Selected drug list and maximum fair price data file (November 2, 2026): Linzess $4.550294 per capsule from January 1, 2027
  4. CMS — Medicare Drug Price Negotiation Program: final guidance and effectuation of the negotiated price (retrospective refunds from drug makers to pharmacies)
  5. CMS — NADAC, as of November 4, 2026: Linzess 290 mcg capsule $9.01398 (effective October 21, 2026); $18.14687 effective December 17, 2025, $9.02534 effective January 1, 2026
  6. NHS dm+d — Constella 290 microgram capsules, 28: NHS indicative price £37.56 (since February 14, 2013)
  7. NHS Business Services Authority — prescription charge £9.90 per item (England)
  8. European Medicines Agency — Constella product information: 290 mcg capsules for irritable bowel syndrome with constipation; EU/1/12/801/002 = 28 capsules
  9. Federal Office of Public Health (BAG) — Spezialitätenliste: Constella 290 mcg, 28 capsules, public price CHF 73.25; cost share 10%
  10. Austrian social insurance (Dachverband) — Erstattungskodex monthly data, November 2026: Constella 290 mcg, 28 capsules, €71.00 (social-insurance price excl. VAT; price model; chief-physician approval (RE1))
  11. oesterreich.gv.at — prescription fee (Rezeptgebühr) €7.55 per pack since January 1, 2026
  12. Zorginstituut Nederland — Medicijnkosten.nl: Constella 290 mcg (EU/1/12/801/002), average price €51.88 per pack, fully reimbursed (updated to November 1, 2026)
  13. Base de données publique des médicaments (France) — no linaclotide product listed (bulk files of November 6, 2026)
  14. BfArM / GKV-Spitzenverband — Festbetrag list as of November 1, 2026 (no entry for linaclotide)
  15. European Central Bank — reference rates, November 5, 2026 (1 US dollar = €0.89095 = £0.74299 = CHF 0.81789)

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Wellness Vision Editorial Policy

Wellness Vision does not sell medicine, recommend pharmacies or suppliers, or take payments from drug makers. Every price above comes from the official source cited; currency conversions and 30-day figures are our own calculations, shown with their formula. This is a cost comparison, not medical advice.

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